Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 9/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 7/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.50 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30889332 | 1.00 | CYP2D6 (0.54) | CYP2D6ALDH1A1POLBTSHRCYP3A4 | |
| SCHEMBL30278414 | 1.00 | CYP2D6 (0.54) | CYP2D6ALDH1A1POLBTSHRCYP3A4 | |
| SCHEMBL6378751 | 0.91 | CYP2D6 (0.57) | CYP2D6ALDH1A1POLBTSHRCYP3A4 | |
| SCHEMBL19613477 | 0.81 | OPRL1 (0.58) | CYP2D6POLBTSHRCYP3A4OPRL1 | |
| SCHEMBL8136038 | 0.81 | CYP2D6 (0.59) | CYP2D6ALDH1A1POLBTSHRCYP3A4 | |
| SCHEMBL951796 | 0.81 | OPRL1 (0.58) | CYP2D6POLBTSHRCYP3A4OPRL1 | |
| SCHEMBL6377977 | 0.80 | CYP2D6 (0.55) | CYP2D6ALDH1A1POLBTSHRCYP3A4 | |
| Hydrochloric Acid SCHEMBL6615899 | 0.80 | POLB (0.59) | CYP2D6POLBTSHRCYP3A4OPRL1 | |
| Bromide SCHEMBL4081272 | 0.80 | CYP2D6 (0.57) | CYP2D6ALDH1A1POLBTSHRCYP3A4 | |
| SCHEMBL568133 | 0.79 | ALDH1A1 (0.58) | CYP2D6ALDH1A1POLBTSHRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4384160-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2024-06-19 | — | — | EP | disclosed |
| CN-117881397-A | Heterocyclic compounds and methods of use | 安进公司 | 2024-04-12 | — | — | CN | disclosed |
| WO-2023018812-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2023-02-16 | — | — | WO | disclosed |