Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12589712 | 0.81 | SIGMAR1 (0.50) | SIGMAR1ALDH1A1MAPK1GFER | |
| SCHEMBL8591720 | 0.80 | SIGMAR1 (0.35) | SIGMAR1ALDH1A1MAPK1GFER | |
| SCHEMBL3151454 | 0.78 | ALDH1A1 (0.60) | ALDH1A1 | |
| SCHEMBL23855085 | 0.77 | — | — | |
| SCHEMBL9665524 | 0.76 | CA1 (0.45) | ALDH1A1 | |
| SCHEMBL13742976 | 0.76 | SIGMAR1 (0.46) | SIGMAR1ALDH1A1MAPK1GFER | |
| SCHEMBL6602215 | 0.72 | — | — | |
| SCHEMBL19871823 | 0.71 | ALDH1A1 (0.38) | SIGMAR1ALDH1A1 | |
| SCHEMBL28254607 | 0.71 | — | — | |
| SCHEMBL805368 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090215805-A1 | 4-Heteroaryl Pyrimidine Derivatives and use thereof as Protein Kinase Inhibitors | CYCLACEL LIMITED (GB) | 2009-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215805-A1 | 4-Heteroaryl Pyrimidine Derivatives and use thereof as Protein Kinase Inhibitors | CDK2, ABL1, CDK20 | SIGMAR1 4559/4885ALDH1A1 2354/4885MAPK1 188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.