Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 8/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 10/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.54 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12860781 | 0.87 | TDP1 (0.68) | TDP1KMT2AL3MBTL1ALDH1A1MAPT | |
| SCHEMBL15504864 | 0.82 | TDP1 (0.66) | TDP1KMT2AL3MBTL1ALDH1A1MAPT | |
| SCHEMBL27772048 | 0.81 | TDP1 (0.60) | TDP1KMT2AL3MBTL1ALDH1A1MAPT | |
| SCHEMBL13283060 | 0.81 | NPC1 (0.50) | TDP1KMT2AL3MBTL1ALDH1A1MAPT | |
| SCHEMBL15514419 | 0.78 | TDP1 (0.60) | TDP1KMT2AL3MBTL1ALDH1A1MAPT | |
| SCHEMBL15504851 | 0.78 | TDP1 (0.60) | TDP1KMT2AL3MBTL1ALDH1A1MAPT | |
| SCHEMBL18133382 | 0.77 | MAPT (0.71) | TDP1KMT2AL3MBTL1ALDH1A1MAPT | |
| SCHEMBL12511943 | 0.76 | L3MBTL1 (0.56) | TDP1KMT2AL3MBTL1ALDH1A1MAPT | |
| SCHEMBL6326324 | 0.76 | TSHR (0.43) | TDP1KMT2AL3MBTL1ALDH1A1MAPT | |
| SCHEMBL135356 | 0.75 | NR4A2 (0.61) | TDP1KMT2AL3MBTL1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095499-A1 | USE OF AMIDOXIME CARBOXYLIC ACID ESTERS AND N-HYDROXYGUANIDINE CARBOXYLIC ACID ESTERS FOR PRODUCING PRODRUGS | DRITTE PATENTPORTFOLIO BETEILIGUNGSGESELLSCHAFT MBH & CO. KG (DE) | 2009-08-06 | — | — | WO | disclosed |