Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 3/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.32 |
| ▸ | IRAK1 | P51617 | 5/20 | 0.32 |
| ▸ | IDO1 | P14902 | 2/20 | 0.32 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.32 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.30 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.30 |
| ▸ | CCNC | P24863 | 1/20 | 0.30 |
| ▸ | CDK8 | P49336 | 1/20 | 0.30 |
| ▸ | CDK9 | P50750 | 1/20 | 0.30 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.30 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.30 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1375389 | 1.00 | TDO2 (0.36) | TDO2CNR2EGLN1NOS3NOS1 | |
| SCHEMBL1375711 | 0.96 | TDO2 (0.37) | TDO2CNR2EGLN1NOS3NOS1 | |
| SCHEMBL1375708 | 0.96 | TDO2 (0.37) | TDO2CNR2EGLN1NOS3NOS1 | |
| SCHEMBL5203028 | 0.92 | IRAK1 (0.36) | EGLN1NOS3NOS1IRAK1TRPC6 | |
| SCHEMBL1376037 | 0.92 | IRAK1 (0.36) | EGLN1NOS3NOS1IRAK1TRPC6 | |
| SCHEMBL1376032 | 0.92 | IRAK1 (0.36) | EGLN1NOS3NOS1IRAK1TRPC6 | |
| SCHEMBL5206015 | 0.92 | TDO2 (0.41) | TDO2CNR2EGLN1NOS3NOS1 | |
| SCHEMBL1376197 | 0.92 | TDO2 (0.41) | TDO2CNR2EGLN1NOS3NOS1 | |
| SCHEMBL1376035 | 0.92 | IRAK1 (0.36) | EGLN1NOS3NOS1IRAK1TRPC6 | |
| SCHEMBL5203021 | 0.92 | IRAK1 (0.36) | EGLN1NOS3NOS1IRAK1TRPC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4743463-B2 | — | — | 2011-08-10 | — | — | JP | claimed |
| JP-2002541245-A | — | — | 2002-12-03 | — | — | JP | claimed |
| EP-1165523-A1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | Krenitsky Pharmaceuticals, Inc. (US) | 2002-01-02 | — | — | EP | claimed |
| WO-2000061562-A1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC. (US) | 2000-10-19 | — | — | WO | claimed |
| EP-1165523-A1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | Krenitsky Pharmaceuticals, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000061562-A1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC. (US) | 2000-10-19 | — | — | WO | disclosed |