Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 18/20 | 0.72 |
| ▸ | CASP3 | P42574 | 1/20 | 0.59 |
| ▸ | CASP6 | P55212 | 1/20 | 0.59 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.58 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7143882 | 1.00 | ADRB2 (0.72) | ADRB2CASP3CASP6ADRB1ADRA1D | |
| SCHEMBL7143881 | 1.00 | ADRB2 (0.72) | ADRB2CASP3CASP6ADRB1ADRA1D | |
| SCHEMBL11174404 | 0.91 | ADRB2 (0.61) | ADRB2CASP3CASP6ADRB1CYP1A2 | |
| SCHEMBL4255178 | 0.88 | ADRB2 (0.88) | ADRB2CASP3CASP6 | |
| SCHEMBL4255179 | 0.88 | ADRB2 (0.88) | ADRB2CASP3CASP6 | |
| SCHEMBL13701206 | 0.87 | ADRB2 (0.68) | ADRB2CYP1A2CYP2D6TSHRNFKB1 | |
| SCHEMBL9661334 | 0.87 | ADRB2 (0.69) | ADRB2CASP3CASP6ADRB1CYP1A2 | |
| SCHEMBL4255273 | 0.87 | ADRB2 (0.72) | ADRB2CASP3CASP6ADRB1 | |
| SCHEMBL4257427 | 0.87 | ADRB2 (0.72) | ADRB2CASP3CASP6ADRB1 | |
| SCHEMBL11807907 | 0.87 | ADRB2 (0.74) | ADRB2CASP3CASP6ADRB1ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1624868-B9 | \"(2-HYDROXY-2-(4-HYDROXY-3-HYDOXYMETHYLPHENYL)-ETHYLAMINO)- PROPYL]PHENYL DERIVATIVES AS BETA2 AGONISTS | PFIZER LTD (GB) | 2009-08-12 | — | — | EP | disclosed |
| EP-1624868-B1 | \"(2-HYDROXY-2-(4-HYDROXY-3-HYDOXYMETHYLPHENYL)-ETHYLAMINO)- PROPYL]PHENYL DERIVATIVES AS BETA2 AGONISTS | PFIZER LTD (GB) | 2008-11-12 | — | — | EP | disclosed |
| US-7268147-B2 | Compounds useful for the treatment of diseases | PFIZER INC (US) | 2007-09-11 | — | — | US | disclosed |
| US-7268147-B2 | Compounds useful for the treatment of diseases | PFIZER INC (US) | 2007-09-11 | — | — | US | disclosed |