Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.40 |
| ▸ | KDR | P35968 | 3/20 | 0.40 |
| ▸ | MET | P08581 | 9/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 3/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | LTK | P29376 | 1/20 | 0.39 |
| ▸ | TTK | P33981 | 1/20 | 0.39 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL427071 | 0.88 | MAPK14 (0.49) | EGFRKDRMETAURKAROCK2 | |
| SCHEMBL14412724 | 0.85 | MAPK14 (0.51) | EGFRKDRMETAURKAROCK2 | |
| SCHEMBL13759171 | 0.77 | EGFR (0.43) | EGFRKDRROCK2SRCEHMT2 | |
| SCHEMBL426551 | 0.75 | GRM4 (0.46) | ALDH1A1MAPT | |
| SCHEMBL427735 | 0.75 | RAB9A (0.46) | ALDH1A1MAPT | |
| SCHEMBL425540 | 0.75 | MAPK14 (0.49) | EGFRKDRMETAURKAROCK2 | |
| SCHEMBL3111928 | 0.74 | RAF1 (0.40) | ALDH1A1 | |
| SCHEMBL13759154 | 0.74 | EHMT2 (0.46) | KDREHMT2EHMT1 | |
| SCHEMBL3114282 | 0.73 | THRB (0.45) | EGFRALDH1A1MAPT | |
| SCHEMBL424718 | 0.73 | EHMT2 (0.52) | KDREHMT2EHMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009100406-A2 | TOPICAL FORMULATIONS FOR THE TREATMENT OF PSORIASIS | SYNTA PHARMACEUTICALS CORP. (US) | 2009-08-13 | — | — | WO | disclosed |