Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.51 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TNF | P01375 | 1/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13759252 | 0.87 | POLB (0.51) | POLBTSHR | |
| SCHEMBL426831 | 0.84 | MAPK14 (0.55) | MAPK14MAPK13MAPK12MAPK11POLB | |
| SCHEMBL13759253 | 0.84 | KDR (0.46) | MAPK14MAPK13MAPK12MAPK11POLB | |
| SCHEMBL13759248 | 0.84 | MAPK14 (0.49) | MAPK14MAPK13MAPK12MAPK11TSHR | |
| SCHEMBL13759001 | 0.83 | KDR (0.49) | MAPK14MAPK13MAPK12MAPK11ALDH1A1 | |
| SCHEMBL14530477 | 0.82 | MAPK13 (0.53) | MAPK14MAPK13MAPK12MAPK11POLB | |
| SCHEMBL13759249 | 0.74 | HRH3 (0.56) | — | |
| SCHEMBL3114122 | 0.72 | KCNA5 (0.46) | MAPK14MAPK13MAPK12MAPK11POLB | |
| SCHEMBL3107346 | 0.72 | POLB (0.47) | MAPK14MAPK13MAPK12MAPK11POLB | |
| SCHEMBL425124 | 0.70 | POLB (0.55) | POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009100406-A2 | TOPICAL FORMULATIONS FOR THE TREATMENT OF PSORIASIS | SYNTA PHARMACEUTICALS CORP. (US) | 2009-08-13 | — | — | WO | disclosed |