Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 14/20 | 0.50 |
| ▸ | CASR | P41180 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 2/20 | 0.46 |
| ▸ | BRAF | P15056 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13759001 | 0.91 | KDR (0.49) | EPHX2HTR2AHTR2CBRAFTSHR | |
| SCHEMBL13759251 | 0.87 | MAPK14 (0.51) | POLBTSHR | |
| SCHEMBL13759248 | 0.86 | MAPK14 (0.49) | EPHX2HTR2AHTR2CBRAFTSHR | |
| SCHEMBL425124 | 0.85 | POLB (0.55) | POLBEPHX2HTR2AHTR2CRAF1 | |
| SCHEMBL13759253 | 0.82 | KDR (0.46) | POLBUSP2 | |
| SCHEMBL13759249 | 0.77 | HRH3 (0.56) | HTR2AHTR2C | |
| SCHEMBL3111943 | 0.75 | AURKB (0.48) | EPHX2HTR2AHTR2C | |
| SCHEMBL428259 | 0.74 | TSHR (0.52) | POLBEPHX2HTR2AHTR2CBRAF | |
| SCHEMBL11926368 | 0.74 | POLB (0.58) | POLBEPHX2CASRHTR2A | |
| SCHEMBL14530764 | 0.73 | NPC1 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009100406-A2 | TOPICAL FORMULATIONS FOR THE TREATMENT OF PSORIASIS | SYNTA PHARMACEUTICALS CORP. (US) | 2009-08-13 | — | — | WO | disclosed |
| WO-2007050980-A2 | PROCESS FOR PREPARING MESYLATE SALTS OF IL-12 INHIBITORY COMPOUNDS | SYNTA PHARMACEUTICALS CORP. (US) | 2007-05-03 | — | — | WO | disclosed |