Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | PREP | P48147 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313304 | 0.88 | NR1H2 (0.53) | HPGDRECQLEPHX1MAPTKDM4E | |
| SCHEMBL24196001 | 0.81 | HPGD (0.44) | HPGDRECQLEPHX1MAPTKDM4E | |
| SCHEMBL13760961 | 0.80 | GPR119 (0.47) | HPGDRECQLEPHX1MAPTKDM4E | |
| SCHEMBL1586009 | 0.80 | GPR119 (0.47) | HPGDRECQLEPHX1MAPTKDM4E | |
| SCHEMBL927984 | 0.80 | GPR119 (0.47) | HPGDRECQLEPHX1MAPTKDM4E | |
| SCHEMBL30783208 | 0.80 | NR1H2 (0.47) | HPGDRECQLEPHX1MAPTKDM4E | |
| SCHEMBL928825 | 0.80 | GPR119 (0.47) | HPGDRECQLEPHX1MAPTKDM4E | |
| SCHEMBL21801914 | 0.80 | NR1H2 (0.47) | HPGDRECQLEPHX1MAPTKDM4E | |
| SCHEMBL21990270 | 0.80 | NR1H2 (0.47) | HPGDRECQLEPHX1MAPTKDM4E | |
| SCHEMBL21913758 | 0.79 | NR1H2 (0.49) | HPGDRECQLEPHX1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009100168-A1 | DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS | GLAXO GROUP LIMITED (GB) | 2009-08-13 | — | — | WO | disclosed |