Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.40 |
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1376171 | 1.00 | RAB9A (0.40) | RAB9ANPC1SMN1; SMN2TP53TSHR | |
| SCHEMBL1379812 | 0.88 | MAPT (0.37) | RAB9ANPC1SMN1; SMN2TP53TSHR | |
| SCHEMBL1379811 | 0.88 | MAPT (0.37) | RAB9ANPC1SMN1; SMN2TP53TSHR | |
| SCHEMBL1378209 | 0.83 | APP (0.34) | MEN1KMT2ACSNK1DMAPTCASP3 | |
| SCHEMBL1378211 | 0.83 | APP (0.34) | MEN1KMT2ACSNK1DMAPTCASP3 | |
| SCHEMBL1376776 | 0.82 | MAPT (0.38) | RAB9ASMN1; SMN2TP53MEN1KMT2A | |
| SCHEMBL1376774 | 0.82 | MAPT (0.38) | RAB9ASMN1; SMN2TP53MEN1KMT2A | |
| SCHEMBL1379232 | 0.81 | NPC1 (0.34) | RAB9ANPC1MAPTTDP1APP | |
| SCHEMBL1379234 | 0.81 | NPC1 (0.34) | RAB9ANPC1MAPTTDP1APP | |
| SCHEMBL1380115 | 0.80 | MAPT (0.36) | MEN1KMT2ALMNAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4727579-B2 | — | — | 2011-07-20 | — | — | JP | claimed |
| US-7897615-B2 | e.g. 2-Cyano-3-hydroxy-N-isopropyl-N-(2-mercapto-benzothiazol-6-yl)-3-(4-trifluoromethyl-phenyl)-acrylamide; cardiovascular disorders, antidiabetic, anticarcinogenic, antiischemic agent; obesity, metabolic disorders | CHUGAI SCIYAKU KABUSHIKI KAISHA (JP) | 2011-03-01 | — | — | US | claimed |
| US-20080161358-A1 | Cyanoamide Compounds Useful as Malonyl-COA Decarboxylase Inhibitors | CHUGAI SEIYAKU KABUSHIKI KAISHA | 2008-07-03 | — | — | US | claimed |
| US-7285562-B2 | Cyanoamide compounds useful as malonyl-CoA decarboxylase inhibitors | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2007-10-23 | — | — | US | claimed |
| EP-1648564-B1 | CYANOAMIDE COMPOUNDS USEFUL AS MALONYL-COA DECARBOXYLASE INHIBITORS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2007-10-17 | — | — | EP | claimed |
| JP-2007501233-A | — | — | 2007-01-25 | — | — | JP | claimed |
| EP-1648564-A1 | CYANOAMIDE COMPOUNDS USEFUL AS MALONYL-COA DECARBOXYLASE INHIBITORS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2006-04-26 | — | — | EP | claimed |
| WO-2005011812-A1 | CYANOAMIDE COMPOUNDS USEFUL AS MALONYL-COA DECARBOXYLASE INHIBITHORS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2005-02-10 | — | — | WO | claimed |
| US-20050026945-A1 | Cyanoamide compounds useful as malonyl-CoA decarboxylase inhibitors | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2005-02-03 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026945-A1 | Cyanoamide compounds useful as malonyl-CoA decarboxylase inhibitors | ACACA, ACACB, MCCC2 | RAB9A 4197/4885NPC1 491/4885SMN1; SMN2 2832/4885 |
| US-20080161358-A1 | Cyanoamide Compounds Useful as Malonyl-COA Decarboxylase Inhibitors | ACACA, ACACB, MCCC2 | RAB9A 4230/4885NPC1 533/4885SMN1; SMN2 3050/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.