Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.50 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.50 |
| ▸ | KHK | P50053 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | CNR2 | P34972 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13762201 | 0.85 | KCNJ6 (0.50) | ADORA2AEPHX2KHKRAB9AKMT2A | |
| SCHEMBL13766425 | 0.83 | SMN1; SMN2 (0.57) | ADORA2AKHKRAB9AKMT2ANPC1 | |
| SCHEMBL2029199 | 0.82 | EPHX2 (0.61) | ADORA2AEPHX2KHKRAB9AKMT2A | |
| SCHEMBL7259516 | 0.82 | EPHX2 (0.61) | ADORA2AEPHX2KHKRAB9AKMT2A | |
| SCHEMBL3640239 | 0.81 | ADORA2A (0.49) | ADORA2AEPHX2KHKRAB9AKMT2A | |
| SCHEMBL7738145 | 0.81 | MITF (0.54) | ADORA2AEPHX2KHKRAB9AKMT2A | |
| SCHEMBL3675224 | 0.76 | PARP1 (0.52) | — | |
| SCHEMBL13762194 | 0.75 | SCN9A (0.62) | RAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL13167582 | 0.74 | CNR2 (0.62) | EPHX2EPHX1RAB9ACNR2KMT2A | |
| SCHEMBL13766292 | 0.74 | SMN1; SMN2 (0.58) | EPHX2KHKKMT2ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7557110-B2 | MAPKAP-K2; inflammatory disease, autoimmune disease, destructive bone disorder, cancer and/or tumour growth; 5-[(trans-4-aminocyclohexyl)amino]-3-fluoro-6-methyl(pyrazolo[1,5-a]pyri- midin-7-yl)}(4-iodophenyl)amine | TEIJIN PHARMA LIMITED (JP) | 2009-07-07 | — | — | US | disclosed |