Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 2/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | PHLPP1 | O60346 | 1/20 | 0.32 |
| ▸ | ILK | Q13418 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4463143 | 0.83 | AKT1 (0.34) | AKT1PDPK1PHLPP1ILK | |
| SCHEMBL4467672 | 0.77 | AKT1 (0.36) | AKT1PDPK1PHLPP1ILK | |
| SCHEMBL13762914 | 0.77 | PTGS1 (0.31) | — | |
| SCHEMBL5340220 | 0.76 | AKT1 (0.32) | AKT1PDPK1PHLPP1ILK | |
| SCHEMBL5315842 | 0.74 | AKT1 (0.33) | AKT1PDPK1PHLPP1ILK | |
| SCHEMBL5314320 | 0.74 | AKT1 (0.33) | AKT1PDPK1PHLPP1ILK | |
| SCHEMBL5316401 | 0.74 | AKT1 (0.33) | AKT1PDPK1PHLPP1ILK | |
| SCHEMBL4476260 | 0.74 | AKT1 (0.33) | AKT1PDPK1PHLPP1ILK | |
| SCHEMBL4469852 | 0.72 | AKT1 (0.34) | AKT1PDPK1PHLPP1ILK | |
| SCHEMBL13763023 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7576094-B2 | Spiro derivatives as lipoxygenase inhibitors | ELI LILLY AND COMPANY (US) | 2009-08-18 | — | — | US | disclosed |