Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 2/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | PHLPP1 | O60346 | 1/20 | 0.33 |
| ▸ | ILK | Q13418 | 1/20 | 0.33 |
| ▸ | FDPS | P14324 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4469852 | 0.80 | AKT1 (0.34) | AKT1PDPK1PHLPP1ILK | |
| SCHEMBL4463143 | 0.79 | AKT1 (0.34) | AKT1PDPK1PHLPP1ILKALOX5 | |
| SCHEMBL4468037 | 0.78 | PTGS1 (0.30) | ALOX5 | |
| SCHEMBL5315842 | 0.75 | AKT1 (0.33) | AKT1PDPK1PHLPP1ILK | |
| SCHEMBL5316401 | 0.75 | AKT1 (0.33) | AKT1PDPK1PHLPP1ILK | |
| SCHEMBL4476260 | 0.75 | AKT1 (0.33) | AKT1PDPK1PHLPP1ILK | |
| SCHEMBL5340220 | 0.74 | AKT1 (0.32) | AKT1PDPK1PHLPP1ILK | |
| SCHEMBL13763085 | 0.74 | AKT1 (0.32) | AKT1PDPK1PHLPP1ILK | |
| SCHEMBL5311023 | 0.73 | GGPS1 (0.30) | FDPS | |
| SCHEMBL4467672 | 0.73 | AKT1 (0.36) | AKT1PDPK1PHLPP1ILKALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7576094-B2 | Spiro derivatives as lipoxygenase inhibitors | ELI LILLY AND COMPANY (US) | 2009-08-18 | — | — | US | disclosed |
| EP-1836183-A2 | SPIRO DERIVATIVES AS LIPOXYGENASE INHIBITORS | Galileo Pharmaceuticals, Inc. (US) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006065686-A2 | SPIRO DERIVATIVES AS LIPOXYGENASE INHIBITORS | GALILEO PHARMACEUTICALS, INC. (US) | 2006-06-22 | — | — | WO | disclosed |