Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 2/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | PHLPP1 | O60346 | 1/20 | 0.33 |
| ▸ | ILK | Q13418 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5315842 | 1.00 | AKT1 (0.33) | AKT1PDPK1PHLPP1ILK | |
| SCHEMBL4476260 | 1.00 | AKT1 (0.33) | AKT1PDPK1PHLPP1ILK | |
| SCHEMBL5317161 | 0.87 | — | — | |
| SCHEMBL5312107 | 0.87 | — | — | |
| SCHEMBL4469852 | 0.87 | AKT1 (0.34) | AKT1PDPK1PHLPP1ILK | |
| SCHEMBL5266292 | 0.83 | AKT1 (0.33) | AKT1PDPK1PHLPP1ILK | |
| SCHEMBL5320882 | 0.82 | CTSD (0.30) | — | |
| SCHEMBL4463143 | 0.79 | AKT1 (0.34) | AKT1PDPK1PHLPP1ILK | |
| SCHEMBL4466962 | 0.78 | PTGS1 (0.30) | — | |
| SCHEMBL5314320 | 0.75 | AKT1 (0.33) | AKT1PDPK1PHLPP1ILK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836183-A2 | SPIRO DERIVATIVES AS LIPOXYGENASE INHIBITORS | Galileo Pharmaceuticals, Inc. (US) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006065686-A2 | SPIRO DERIVATIVES AS LIPOXYGENASE INHIBITORS | GALILEO PHARMACEUTICALS, INC. (US) | 2006-06-22 | — | — | WO | disclosed |