Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | NPC1 | O15118 | 5/20 | 0.62 |
| ▸ | RAB9A | P51151 | 5/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6850999 | 0.91 | KDM4E (0.79) | KDM4ENPC1RAB9ATDP1POLB | |
| SCHEMBL6857849 | 0.84 | KDM4E (0.70) | KDM4ENPC1RAB9ATDP1POLB | |
| SCHEMBL10783486 | 0.81 | KDM4E (1.00) | KDM4ENPC1RAB9ATDP1POLB | |
| SCHEMBL25668512 | 0.80 | TDP1 (0.68) | KDM4ENPC1RAB9ATDP1POLB | |
| SCHEMBL6790850 | 0.80 | TDP1 (0.61) | NPC1RAB9ATDP1POLBHDAC1 | |
| SCHEMBL9613267 | 0.80 | NPC1 (0.64) | KDM4ENPC1RAB9ATDP1POLB | |
| SCHEMBL12597618 | 0.78 | KDM4E (0.68) | KDM4ENPC1RAB9ATDP1POLB | |
| SCHEMBL9613284 | 0.78 | KDM4E (0.67) | KDM4ENPC1RAB9ATDP1POLB | |
| SCHEMBL12894486 | 0.78 | KIF11 (0.56) | KDM4ENPC1RAB9APOLBSMN1; SMN2 | |
| SCHEMBL26333987 | 0.78 | KDM4E (0.61) | KDM4ENPC1RAB9ATDP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7576079-B2 | Viral polymerase inhibitors | BOEHRINGER INGELHEIM (CANADA) LTD. (CA) | 2009-08-18 | — | — | US | disclosed |