Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.56 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1275920 | 0.88 | ALDH1A1 (0.70) | TDP1POLBNPC1ALDH1A1MAPT | |
| SCHEMBL8646083 | 0.84 | ALDH1A1 (0.68) | TDP1POLBNPC1ALDH1A1MAPT | |
| SCHEMBL172125 | 0.82 | ALDH1A1 (0.67) | TDP1POLBNPC1ALDH1A1MAPT | |
| SCHEMBL3183978 | 0.80 | TDP1 (0.59) | TDP1POLBNPC1ALDH1A1MAPT | |
| SCHEMBL21597432 | 0.80 | TDP1 (0.59) | TDP1POLBNPC1ALDH1A1MAPT | |
| SCHEMBL16556378 | 0.80 | ALDH1A1 (0.64) | TDP1POLBNPC1ALDH1A1MAPT | |
| SCHEMBL13763233 | 0.80 | KDM4E (0.68) | TDP1POLBNPC1ALDH1A1MAPT | |
| SCHEMBL19965684 | 0.80 | TDP1 (0.59) | TDP1POLBNPC1ALDH1A1MAPT | |
| SCHEMBL1310905 | 0.80 | MAOA (0.67) | TDP1POLBNPC1ALDH1A1MAPT | |
| SCHEMBL366747 | 0.80 | SMN1; SMN2 (0.74) | NPC1ALDH1A1MAPTRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1192015-C | Cell adhesion inhibitors | BIOGEN INC (US) | 2005-03-09 | — | — | CN | claimed |
| CN-1177343-A | Cell adhesion inhibitors | BIOGEN INC (US) | 1998-03-25 | — | — | CN | claimed |
| US-9580553-B2 | Thermally-activated self-immolative materials | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (US) | 2017-02-28 | — | — | US | disclosed |
| US-20150368403-A1 | THERMALLY-ACTIVATED SELF-IMMOLATIVE MATERIALS | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (US) | 2015-12-24 | — | — | US | disclosed |
| WO-2014133620-A2 | THERMALLY-ACTIVATED SELF-IMMOLATIVE MATERIALS | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (US) | 2014-09-04 | — | — | WO | disclosed |
| CN-1192015-C | Cell adhesion inhibitors | BIOGEN INC (US) | 2005-03-09 | — | — | CN | disclosed |
| US-6713629-B2 | PLANT FUNGICIDE | NIPPON SODA CO., LTD. (JP) | 2004-03-30 | — | — | US | disclosed |
| CN-1177343-A | Cell adhesion inhibitors | BIOGEN INC (US) | 1998-03-25 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150368403-A1 | THERMALLY-ACTIVATED SELF-IMMOLATIVE MATERIALS | PARG, PAICS, LRBA | TDP1 25/4885POLB 782/4885NPC1 4727/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.