Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | HTR7 | P34969 | 2/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | FPR3 | P25089 | 1/20 | 0.46 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
| ▸ | GPR183 | P32249 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16578994 | 0.82 | HTR1A (0.68) | HTR1AADRA2AADRA2CADRA1DADRA1A | |
| SCHEMBL1323756 | 0.80 | HTR1A (0.70) | HTR1AADRA2AADRA2CADRA1DADRA1A | |
| SCHEMBL1323812 | 0.80 | HTR1A (0.65) | HTR1AADRA2AADRA2CADRA1DADRA1A | |
| SCHEMBL1322969 | 0.78 | HTR1A (0.57) | HTR1AHTR1DHTR1B | |
| SCHEMBL1406042 | 0.77 | HTR1A (0.57) | HTR1AADRA2AADRA2CADRA1DADRA1A | |
| SCHEMBL13633559 | 0.77 | ADRA2A (0.48) | HTR1AADRA2AADRA2CADRA1DADRA1A | |
| SCHEMBL27480588 | 0.76 | HTR1A (0.68) | HTR1AADRA2AADRA2CADRA1DADRA1A | |
| SCHEMBL1323781 | 0.75 | HTR1A (0.43) | HTR1AADRA2AADRA2CADRA1DADRA1A | |
| SCHEMBL1323787 | 0.75 | HTR1A (0.53) | HTR1AADRA2AADRA2CADRA1DADRA1A | |
| SCHEMBL1322976 | 0.75 | HTR1A (0.51) | HTR1AADRA2AADRA2CADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7572796-B2 | Substituted indoles | MERCK PATENT GMBH (DE) | 2009-08-11 | — | — | US | disclosed |