Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.59 |
| ▸ | NPC1 | O15118 | 7/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | ALDH1A3 | P47895 | 4/20 | 0.56 |
| ▸ | ALDH1A2 | O94788 | 2/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | TMIGD3 | P0DMS9 | 3/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 4/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.43 |
| ▸ | RELA | Q04206 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3520105 | 0.89 | RAB9A (0.55) | RAB9AALDH1A1NPC1KDM4EPKM | |
| SCHEMBL18189922 | 0.89 | ALDH1A3 (0.58) | RAB9AALDH1A1NPC1KDM4EPKM | |
| SCHEMBL6648749 | 0.85 | ALDH1A3 (0.46) | RAB9AALDH1A1NPC1KDM4EPKM | |
| SCHEMBL14164602 | 0.82 | ALDH1A3 (0.46) | RAB9AALDH1A1NPC1KDM4EPKM | |
| SCHEMBL14164478 | 0.80 | KDM4E (0.40) | RAB9AALDH1A1NPC1KDM4EPKM | |
| SCHEMBL14164482 | 0.80 | RAB9A (0.44) | RAB9AALDH1A1NPC1KDM4EPKM | |
| SCHEMBL14164514 | 0.79 | RAB9A (0.58) | RAB9AALDH1A1NPC1KDM4EPKM | |
| SCHEMBL13776789 | 0.78 | EPHB4 (0.44) | RAB9AALDH1A1NPC1KDM4EPKM | |
| SCHEMBL19664874 | 0.76 | RAB9A (0.51) | RAB9AALDH1A1NPC1KDM4EPKM | |
| SCHEMBL8240492 | 0.75 | TMIGD3 (0.52) | RAB9AALDH1A1NPC1KDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090175852-A1 | IMIDAZOPYRAZINES AS PROTEIN KINASE INHIBITORS | SCHERING CORPORATION | 2009-07-09 | — | — | US | disclosed |
| US-7557104-B2 | Imidazopyrazines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2009-07-07 | — | — | US | disclosed |
| US-7557104-B2 | Imidazopyrazines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2009-07-07 | — | — | US | disclosed |
| US-20080027063-A1 | IMIDAZOPYRAZINES AS PROTEIN KINASE INHIBITORS | SCHERING CORPORATION | 2008-01-31 | — | — | US | disclosed |
| US-20080027063-A1 | IMIDAZOPYRAZINES AS PROTEIN KINASE INHIBITORS | SCHERING CORPORATION | 2008-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080027063-A1 | IMIDAZOPYRAZINES AS PROTEIN KINASE INHIBITORS | CHEK1, CHEK2, CDKN1A | RAB9A 3242/4885ALDH1A1 3481/4885NPC1 3810/4885 |
| US-20090175852-A1 | IMIDAZOPYRAZINES AS PROTEIN KINASE INHIBITORS | CHEK1, CHEK2, CDKN1A | RAB9A 3242/4885ALDH1A1 3481/4885NPC1 3810/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.