Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 13/20 | 0.60 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.60 |
| ▸ | PRMT3 | O60678 | 6/20 | 0.58 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.51 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13764333 | 0.99 | ROCK2 (0.61) | ROCK2ROCK1PRMT3IMPDH2MYLK4 | |
| SCHEMBL1123677 | 0.95 | ROCK2 (0.54) | ROCK2ROCK1PRMT3 | |
| SCHEMBL14562668 | 0.95 | ROCK2 (0.54) | ROCK2ROCK1PRMT3 | |
| SCHEMBL1123536 | 0.94 | ROCK2 (0.55) | ROCK2ROCK1PRMT3 | |
| SCHEMBL14562581 | 0.94 | ROCK2 (0.55) | ROCK2ROCK1PRMT3 | |
| Hydrochloric Acid SCHEMBL1096178 | 0.89 | PRMT3 (0.49) | ROCK2ROCK1PRMT3IMPDH2 | |
| SCHEMBL14562791 | 0.87 | PRMT3 (0.52) | ROCK2ROCK1PRMT3IMPDH2 | |
| SCHEMBL1124261 | 0.87 | PRMT3 (0.52) | ROCK2ROCK1PRMT3IMPDH2 | |
| SCHEMBL30846657 | 0.85 | PRMT3 (0.56) | ROCK2ROCK1PRMT3IMPDH2 | |
| SCHEMBL1124139 | 0.85 | PRMT3 (0.51) | ROCK2ROCK1PRMT3IMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2546239-B1 | 6-AMINO ISOQUINOLINS COMPOUNDS AND METHODS FOR MAKING THE SAME | AERIE PHARMACEUTICALS INC (US) | 2015-04-08 | — | — | EP | disclosed |
| US-8871757-B2 | 6-and 7-amino isoquinoline compounds and methods for making and using the same | AERIE PHARMACEUTICALS, INC. (US) | 2014-10-28 | — | — | US | disclosed |
| EP-2546238-A1 | 6-AMINO ISOQUINOLINS COMPOUNDS AND METHODS FOR MAKING THE SAME | AERIE PHARMACEUTICALS, INC. (US) | 2013-01-16 | — | — | EP | disclosed |
| EP-2546239-A1 | 6-AMINO ISOQUINOLINS COMPOUNDS AND METHODS FOR MAKING THE SAME | AERIE PHARMACEUTICALS, INC. (US) | 2013-01-16 | — | — | EP | disclosed |
| WO-2009091898-A2 | 6-AND 7-AMINO ISOQUINOLINE COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME | AERIE PHARMACEUTICALS, INC. (US) | 2009-07-23 | — | — | WO | disclosed |