Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 8/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.34 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4057661 | 0.93 | PDE10A (0.42) | PDE10AMAPK14MAOACYSLTR2CYSLTR1 | |
| SCHEMBL4052937 | 0.84 | MAPK14 (0.40) | PDE10AMAPK14MEN1KMT2ACYSLTR2 | |
| SCHEMBL14159707 | 0.80 | PDE10A (0.39) | PDE10ACYSLTR2CYSLTR1ALOX5AP | |
| SCHEMBL13765233 | 0.80 | PDE10A (0.39) | PDE10ACYSLTR2CYSLTR1ALOX5AP | |
| SCHEMBL4060094 | 0.78 | CYSLTR2 (0.39) | PDE10AMAPK14CYSLTR2CYSLTR1ALOX5AP | |
| SCHEMBL7801392 | 0.78 | MAPT (0.48) | MAOAMEN1KMT2A | |
| SCHEMBL4057651 | 0.77 | CYSLTR2 (0.38) | PDE10AMAPK14CYSLTR2CYSLTR1HTR2B | |
| SCHEMBL4055028 | 0.76 | MAPK14 (0.42) | PDE10AMAPK14MEN1KMT2ACYSLTR2 | |
| SCHEMBL4050759 | 0.75 | CYSLTR2 (0.39) | PDE10ACYSLTR2CYSLTR1ALOX5APHTR2B | |
| SCHEMBL4052136 | 0.74 | CYSLTR2 (0.36) | PDE10ACYSLTR2CYSLTR1ALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7557212-B2 | Tricyclic derivatives as LTD4 antagonists | LABORATORIOS ALMIRALL, S.A. (ES) | 2009-07-07 | — | — | US | disclosed |
| US-7557212-B2 | Tricyclic derivatives as LTD4 antagonists | LABORATORIOS ALMIRALL, S.A. (ES) | 2009-07-07 | — | — | US | disclosed |