Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | LTB4R | Q15722 | 4/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 6/20 | 0.34 |
| ▸ | CYSLTR1 | Q9Y271 | 3/20 | 0.34 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4058527 | 0.93 | PDE10A (0.41) | PDE10ALTB4RALOX5APCYSLTR1CYSLTR2 | |
| SCHEMBL14159707 | 0.90 | PDE10A (0.39) | PDE10ALTB4RALOX5APCYSLTR1CYSLTR2 | |
| SCHEMBL4052528 | 0.85 | LTB4R (0.43) | PDE10ALTB4RALOX5APCYSLTR1CYSLTR2 | |
| SCHEMBL4052136 | 0.83 | CYSLTR2 (0.36) | PDE10AALOX5APCYSLTR1CYSLTR2 | |
| SCHEMBL14159715 | 0.83 | ALOX5AP (0.34) | PDE10AALOX5APCYSLTR1CYSLTR2ALOX5 | |
| SCHEMBL4059510 | 0.80 | CYSLTR2 (0.33) | PDE10AALOX5APCYSLTR1CYSLTR2ALOX5 | |
| SCHEMBL4059512 | 0.80 | CYSLTR2 (0.33) | PDE10AALOX5APCYSLTR1CYSLTR2ALOX5 | |
| SCHEMBL13765232 | 0.80 | PDE10A (0.39) | PDE10AALOX5APCYSLTR1CYSLTR2 | |
| SCHEMBL4060756 | 0.80 | PDE10A (0.41) | PDE10ALTB4RALOX5APCYSLTR1CYSLTR2 | |
| SCHEMBL7801372 | 0.79 | LTB4R (0.43) | PDE10ALTB4RALOX5APCYSLTR1CYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7557212-B2 | Tricyclic derivatives as LTD4 antagonists | LABORATORIOS ALMIRALL, S.A. (ES) | 2009-07-07 | — | — | US | disclosed |
| US-7557212-B2 | Tricyclic derivatives as LTD4 antagonists | LABORATORIOS ALMIRALL, S.A. (ES) | 2009-07-07 | — | — | US | disclosed |