Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.39 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 13/20 | 0.39 |
| ▸ | PDE4A | P27815 | 3/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4057661 | 0.81 | PDE10A (0.42) | CYSLTR2CYSLTR1PDE10AHTR2B | |
| SCHEMBL4058205 | 0.80 | CYSLTR2 (0.39) | CYSLTR2CYSLTR1PDE10APDE4APDE4B | |
| SCHEMBL4060094 | 0.76 | CYSLTR2 (0.39) | CYSLTR2CYSLTR1PDE10APDE4APDE4B | |
| SCHEMBL13765232 | 0.75 | PDE10A (0.39) | CYSLTR2CYSLTR1PDE10AALOX5APHTR2B | |
| SCHEMBL4057651 | 0.75 | CYSLTR2 (0.38) | CYSLTR2CYSLTR1PDE10APDE4APDE4B | |
| SCHEMBL4055028 | 0.75 | MAPK14 (0.42) | CYSLTR2CYSLTR1PDE10AALOX5HTR2B | |
| SCHEMBL4049947 | 0.74 | CYSLTR2 (0.39) | CYSLTR2CYSLTR1ALOX5AP | |
| SCHEMBL4057906 | 0.73 | PDE10A (0.40) | CYSLTR2CYSLTR1PDE10AALOX5 | |
| SCHEMBL4052947 | 0.72 | CYSLTR2 (0.39) | CYSLTR2CYSLTR1ALOX5AP | |
| SCHEMBL4054259 | 0.71 | LMNA (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7557212-B2 | Tricyclic derivatives as LTD4 antagonists | LABORATORIOS ALMIRALL, S.A. (ES) | 2009-07-07 | — | — | US | disclosed |
| US-7557212-B2 | Tricyclic derivatives as LTD4 antagonists | LABORATORIOS ALMIRALL, S.A. (ES) | 2009-07-07 | — | — | US | disclosed |
| US-7557212-B2 | Tricyclic derivatives as LTD4 antagonists | LABORATORIOS ALMIRALL, S.A. (ES) | 2009-07-07 | — | — | US | disclosed |
| EP-1560834-B1 | NEW TRICYCLIC DERIVATIVES AS LTD4 ANTAGONISTS | ALMIRALL LAB (ES) | 2008-06-25 | — | — | EP | disclosed |