Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 19/20 | 0.64 |
| ▸ | CSF1R | P07333 | 2/20 | 0.63 |
| ▸ | KIT | P10721 | 2/20 | 0.63 |
| ▸ | FLT3 | P36888 | 2/20 | 0.63 |
| ▸ | ACHE | P22303 | 1/20 | 0.59 |
| ▸ | BACE1 | P56817 | 1/20 | 0.59 |
| ▸ | PLK4 | O00444 | 1/20 | 0.58 |
| ▸ | GAK | O14976 | 1/20 | 0.58 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.58 |
| ▸ | STK10 | O94804 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 1/20 | 0.58 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.58 |
| ▸ | LCK | P06239 | 1/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.58 |
| ▸ | SRC | P12931 | 1/20 | 0.58 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.58 |
| ▸ | FLT1 | P17948 | 1/20 | 0.58 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.58 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.58 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13330552 | 0.87 | PDGFRB (0.65) | PDGFRBCSF1RKITFLT3PLK4 | |
| SCHEMBL2475194 | 0.83 | PDGFRB (0.70) | PDGFRBCSF1RKITFLT3PLK4 | |
| SCHEMBL7154857 | 0.80 | TLR9 (0.65) | PDGFRBCSF1RKITFLT3ACHE | |
| SCHEMBL20828299 | 0.80 | TLR9 (0.77) | PDGFRBCSF1RKITFLT3ACHE | |
| SCHEMBL1132488 | 0.80 | KIT (0.65) | PDGFRBKIT | |
| SCHEMBL906341 | 0.78 | PDGFRB (1.00) | PDGFRB | |
| SCHEMBL13330462 | 0.78 | PDGFRB (1.00) | PDGFRBCSF1RKITFLT3PLK4 | |
| SCHEMBL11797415 | 0.77 | ACHE (0.76) | PDGFRBKITFLT3ACHEBACE1 | |
| SCHEMBL13168045 | 0.77 | PDGFRB (0.83) | PDGFRBCSF1RKITFLT3PLK4 | |
| SCHEMBL13355149 | 0.77 | PDGFRB (0.83) | PDGFRBCSF1RKITFLT3PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7560461-B2 | Quinazoline derivatives as kinase inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-07-14 | — | — | US | disclosed |