Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.56 |
| ▸ | GSK3B | P49841 | 1/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6286010 | 0.86 | HDAC3 (0.56) | L3MBTL1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL19642535 | 0.86 | GSK3B (0.65) | L3MBTL1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3830886 | 0.84 | HDAC3 (0.61) | L3MBTL1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL10780575 | 0.83 | L3MBTL1 (0.58) | L3MBTL1HDAC3HDAC4HDAC1HDAC7 | |
| Hydrochloric Acid SCHEMBL28047842 | 0.82 | HDAC3 (0.59) | L3MBTL1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL31274111 | 0.82 | HDAC3 (0.59) | L3MBTL1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1373049 | 0.82 | HDAC3 (0.56) | L3MBTL1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1376488 | 0.81 | L3MBTL1 (0.56) | L3MBTL1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7797596 | 0.81 | L3MBTL1 (0.56) | L3MBTL1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7802060 | 0.81 | L3MBTL1 (0.56) | L3MBTL1HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5641811-A | USING A 3-(SUBSTITUTED BENZOYLPROPIONIC ACID AS A TASTAND TO REDUCE OR ELIMINATE A BITTER OR METALLIC TASTE; FOODS, DRUGS; SUBSTITUTES | BIORESEARCH INC. (US) | 1997-06-24 | — | — | US | claimed |
| EP-0727151-A2 | Ingestibles containing substantially tasteless sweetness inhibitors as bitter taste reducers or substantially tasteless bitter inhibitors as sweet taste reducers | BIORESEARCH, INC. (US) | 1996-08-21 | — | — | EP | claimed |
| EP-0661932-A4 | SPECIFIC EATABLE TASTE MODIFIERS. | BIORESEARCH INC (US) | 1996-06-05 | — | — | EP | claimed |
| EP-0661932-A1 | SPECIFIC EATABLE TASTE MODIFIERS | BIORESEARCH, INC. (US) | 1995-07-12 | — | — | EP | claimed |
| WO-1993010677-A1 | SPECIFIC EATABLE TASTE MODIFIERS | BIORESEARCH, INC. (US) | 1993-06-10 | — | — | WO | claimed |
| EP-0156317-A2 | Foodstuffs containing sweetness inhibiting agents and process for inhibiting the sweetness perception of a foodstuff | GENERAL FOODS CORPORATION (US) | 1985-10-02 | — | — | EP | claimed |
| US-4544565-A | ARYLALKYLKETONES | GENERAL FOODS CORPORATION (US) | 1985-10-01 | — | — | US | claimed |
| EP-2502918-B1 | Pyridazinone Derivatives | CEPHALON INC (US) | 2015-03-25 | — | — | EP | disclosed |
| US-20140142088-A1 | PYRIDAZINONE DERIVATIVES | CEPHALON, INC. (US) | 2014-05-22 | — | — | US | disclosed |
| US-8673916-B2 | Methods of treating disorders mediated by histamine H3 receptors using pyridazinone derivatives | CEPHALON, INC. (US) | 2014-03-18 | — | — | US | disclosed |
| US-8586588-B2 | Aryl pyridazinone derivatives and their use as H3 receptor ligands | CEPHALON, INC. (US) | 2013-11-19 | — | — | US | disclosed |
| EP-2069312-B1 | PYRIDIZINONE DERIVATIVES | CEPHALON INC (US) | 2012-11-07 | — | — | EP | disclosed |
| EP-2502918-A1 | Pyridizinone Derivatives | Cephalon, Inc. (US) | 2012-09-26 | — | — | EP | disclosed |
| EP-0727149-A2 | Ingestibles containing substantially tasteless sweetness inhibitors as bitter taste reducers or substantially tasteless bitter inhibitors as sweet taste reducers | BIORESEARCH, INC. (US) | 1996-08-21 | — | — | EP | disclosed |
| EP-0661932-A4 | SPECIFIC EATABLE TASTE MODIFIERS. | BIORESEARCH INC (US) | 1996-06-05 | — | — | EP | disclosed |
| EP-0661932-A1 | SPECIFIC EATABLE TASTE MODIFIERS | BIORESEARCH, INC. (US) | 1995-07-12 | — | — | EP | disclosed |
| US-5232735-A | INGESTIBLES CONTAINING SUBSTANTIALLY TASTELESS SWEETNESS INHIBITORS AS BITTER TASTE REDUCERS OR SUBSTANTIALLY TASTELESS BITTER INHIBITORS AS SWEET TASTE REDUCERS | BIORESEARCH, INC. (US) | 1993-08-03 | — | — | US | disclosed |
| WO-1993010677-A1 | SPECIFIC EATABLE TASTE MODIFIERS | BIORESEARCH, INC. (US) | 1993-06-10 | — | — | WO | disclosed |
| EP-0156317-A2 | Foodstuffs containing sweetness inhibiting agents and process for inhibiting the sweetness perception of a foodstuff | GENERAL FOODS CORPORATION (US) | 1985-10-02 | — | — | EP | disclosed |
| US-4544565-A | ARYLALKYLKETONES | GENERAL FOODS CORPORATION (US) | 1985-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140142088-A1 | PYRIDAZINONE DERIVATIVES | HRH3, HNMT, HRH4 | L3MBTL1 3510/4885HDAC3 368/4885HDAC4 175/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.