Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 13/20 | 0.77 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13405733 | 0.87 | CSF1R (1.00) | CSF1R | |
| SCHEMBL13767720 | 0.84 | CSF1R (0.56) | CSF1RPOLBATMKDM4EALDH1A1 | |
| SCHEMBL3538933 | 0.77 | CSF1R (0.78) | CSF1R | |
| SCHEMBL3544978 | 0.76 | CSF1R (0.79) | CSF1R | |
| SCHEMBL13405740 | 0.73 | CSF1R (0.70) | CSF1RKDM4EALDH1A1GAA | |
| SCHEMBL13405750 | 0.73 | CSF1R (0.76) | CSF1R | |
| SCHEMBL13405741 | 0.73 | CSF1R (0.76) | CSF1R | |
| SCHEMBL3958266 | 0.73 | CSF1R (0.75) | CSF1R | |
| SCHEMBL3535973 | 0.73 | HTR3A (0.49) | CSF1RKDM4EALDH1A1GAA | |
| SCHEMBL13405654 | 0.72 | CSF1R (0.75) | CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807407-B1 | AROMATIC AMIDES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2009-07-29 | — | — | EP | disclosed |