Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | AR | P10275 | 8/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | XBP1 | P17861 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13768523 | 0.84 | AR (0.55) | HTTTDP1ARKCNH2ALOX15 | |
| SCHEMBL13768702 | 0.80 | DPP4 (0.44) | HTTTDP1ARKCNH2ALOX15 | |
| SCHEMBL13768525 | 0.79 | DPP4 (0.42) | HTTTDP1ARKCNH2ALOX15 | |
| SCHEMBL2266153 | 0.75 | DGAT1 (0.56) | HTTTDP1ARKCNH2ALOX15 | |
| SCHEMBL2266490 | 0.74 | MAPT (0.72) | HTTTDP1ARKCNH2ALOX15 | |
| SCHEMBL2265872 | 0.73 | AR (0.59) | HTTTDP1ARKCNH2ALOX15 | |
| SCHEMBL2267284 | 0.72 | HTT (0.53) | HTTTDP1ARKCNH2ALOX15 | |
| SCHEMBL14411889 | 0.72 | HTR1A (0.52) | HTTL3MBTL1 | |
| SCHEMBL2266723 | 0.71 | AR (0.77) | HTTTDP1ARKCNH2ALOX15 | |
| SCHEMBL2266429 | 0.70 | AR (0.65) | HTTTDP1ARKCNH2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009081197-A1 | BICYCLIC DERIVATIVES FOR USE IN THE TREATMENT OF ANDROGEN RECEPTOR ASSOCIATED CONDITIONS | ASTRAZENECA AB (SE) | 2009-07-02 | — | — | WO | disclosed |