Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.50 |
| ▸ | HPGD | P15428 | 8/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | PSMD14 | O00487 | 2/20 | 0.46 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4036640 | 0.87 | ALDH1A1 (0.55) | ALDH1A1KDM4EHPGDHSD17B10HTT | |
| SCHEMBL14040562 | 0.85 | ALDH1A1 (0.63) | ALDH1A1KDM4EHPGDHSD17B10HTT | |
| SCHEMBL4033196 | 0.82 | ALDH1A1 (0.64) | ALDH1A1KDM4EHPGDHSD17B10HTT | |
| SCHEMBL4035062 | 0.81 | ALDH1A1 (0.57) | ALDH1A1KDM4EHPGDHSD17B10HTT | |
| SCHEMBL9944361 | 0.80 | ALDH1A1 (0.60) | ALDH1A1KDM4EHDAC6MAPTKMT2A | |
| SCHEMBL19631381 | 0.71 | ALDH1A1 (0.72) | ALDH1A1KDM4EHPGDHSD17B10HTT | |
| SCHEMBL160054 | 0.70 | MAPT (0.50) | ALDH1A1KDM4EHTTTP53MAPT | |
| SCHEMBL9944362 | 0.69 | KDM4E (0.48) | ALDH1A1KDM4EHPGDHSD17B10HTT | |
| SCHEMBL15219839 | 0.69 | KDM4E (0.75) | ALDH1A1KDM4EHPGDHSD17B10HTT | |
| SCHEMBL14478894 | 0.69 | LMNA (0.65) | ALDH1A1KDM4EHPGDMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1635821-B1 | 4-BROMO-5-(2-CHLORO-BENZOYLAMINO)-1H-PYRAZOLE-3-CARBOXYLIC ACID (PHENYL)AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B1 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ELAN PHARM INC (US) | 2009-07-08 | — | — | EP | disclosed |