Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 8/20 | 0.43 |
| ▸ | ERCC1 | P07992 | 3/20 | 0.43 |
| ▸ | ERCC4 | Q92889 | 3/20 | 0.43 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 2/20 | 0.39 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3434715 | 0.87 | SIGMAR1 (0.46) | TRPV1TRPV3BACE1POLBLMNA | |
| SCHEMBL3406592 | 0.86 | CNR1 (0.44) | TRPV1TRPV3CNR1CNR2BACE1 | |
| SCHEMBL3431268 | 0.85 | TRPV3 (0.49) | TRPV1TRPV3BACE1CTSDEPHX2 | |
| SCHEMBL619006 | 0.80 | CNR1 (0.50) | TRPV1TRPV3CNR1CNR2BACE1 | |
| SCHEMBL3805039 | 0.79 | TRPV3 (0.47) | TRPV1TRPV3CNR1CNR2BACE1 | |
| SCHEMBL13065082 | 0.79 | TRPV3 (0.40) | TRPV1TRPV3CNR1CNR2BACE1 | |
| SCHEMBL13064916 | 0.79 | TRPV3 (0.40) | TRPV1TRPV3CNR1CNR2BACE1 | |
| SCHEMBL3802222 | 0.78 | CNR1 (0.44) | TRPV1TRPV3CNR1CNR2BACE1 | |
| SCHEMBL3798843 | 0.78 | CNR1 (0.42) | TRPV1TRPV3CNR1CNR2BACE1 | |
| SCHEMBL3799654 | 0.78 | TRPV3 (0.47) | TRPV1TRPV3CNR1CNR2BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009084034-A2 | CHROMANE DERIVATIVES AS TRPV3 MODULATORS | GLENMARK PHARMACEUTICALS, S. A. (CH) | 2009-07-09 | — | — | WO | disclosed |