Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 3/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.36 |
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 2/20 | 0.34 |
| ▸ | MELK | Q14680 | 1/20 | 0.34 |
| ▸ | HRH2 | P25021 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9610931 | 0.86 | ABL1 (0.43) | MAP4K4LTA4HGRM2HDAC1 | |
| SCHEMBL5952730 | 0.83 | HDAC1 (0.50) | MAP4K4LTA4HGRM2HDAC1HRH3 | |
| SCHEMBL10288535 | 0.81 | LTA4H (0.55) | MAP4K4LTA4HGRM2HDAC1HRH3 | |
| SCHEMBL15587398 | 0.75 | MAP4K4 (0.52) | MAP4K4LTA4HNSD2GRM2HDAC1 | |
| SCHEMBL17896882 | 0.75 | MAP4K4 (0.52) | MAP4K4LTA4HNSD2GRM2HDAC1 | |
| SCHEMBL24192364 | 0.74 | MAP4K4 (0.56) | MAP4K4LTA4HNSD2GRM2HDAC1 | |
| SCHEMBL30384683 | 0.73 | LTA4H (0.43) | MAP4K4LTA4HNSD2GRM2HDAC1 | |
| SCHEMBL1911332 | 0.73 | LTA4H (0.60) | LTA4HHDAC1KDM1A | |
| SCHEMBL13634431 | 0.73 | LTA4H (0.60) | LTA4HHDAC1KDM1A | |
| SCHEMBL13024536 | 0.73 | LTA4H (0.60) | LTA4HHDAC1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090176781-A1 | Acetylenic Heteroaryl Compounds | ARIAD PHARMACEUTICALS, INC. | 2009-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090176781-A1 | Acetylenic Heteroaryl Compounds | NAT1, AADAC, ACACA | MAP4K4 3898/4885LTA4H 332/4885NSD2 1146/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.