Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 14/20 | 0.58 |
| ▸ | DDR2 | Q16832 | 6/20 | 0.57 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.57 |
| ▸ | KIT | P10721 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13765911 | 0.88 | DDR1 (0.68) | BRAFDDR2DDR1KIT | |
| SCHEMBL13219899 | 0.81 | DDR2 (0.63) | BRAFDDR2DDR1KIT | |
| SCHEMBL1077175 | 0.80 | BRAF (0.52) | BRAFDDR2DDR1KIT | |
| SCHEMBL13659892 | 0.80 | BRAF (0.62) | BRAFDDR2DDR1KIT | |
| SCHEMBL13219960 | 0.79 | DDR2 (0.72) | DDR2DDR1KIT | |
| SCHEMBL9611068 | 0.79 | DDR2 (0.67) | BRAFDDR2DDR1KIT | |
| SCHEMBL2304393 | 0.78 | TRPA1 (0.60) | BRAFDDR2DDR1KIT | |
| SCHEMBL13219897 | 0.77 | DDR2 (0.68) | DDR2DDR1KIT | |
| SCHEMBL13772098 | 0.77 | ABL1 (0.60) | BRAFDDR2DDR1KIT | |
| SCHEMBL1075954 | 0.77 | BRAF (0.55) | BRAFDDR2DDR1KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130018046-A1 | Acetylenic Heteroaryl Compounds | ARIAD PHARMACEUTICALS, INC. (US) | 2013-01-17 | — | — | US | disclosed |
| US-20090176781-A1 | Acetylenic Heteroaryl Compounds | ARIAD PHARMACEUTICALS, INC. | 2009-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090176781-A1 | Acetylenic Heteroaryl Compounds | NAT1, AADAC, ACACA | BRAF 3990/4885DDR2 4117/4885DDR1 4768/4885 |
| US-20130018046-A1 | Acetylenic Heteroaryl Compounds | NAT1, AADAC, ACACA | BRAF 3990/4885DDR2 4117/4885DDR1 4768/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.