Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | CCR9 | P51686 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | RBP4 | P02753 | 2/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.35 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4118466 | 0.85 | ALDH1A1 (0.37) | ALDH1A1L3MBTL1CCR9RBP4HPGD | |
| SCHEMBL13775851 | 0.85 | LPAR1 (0.40) | METAP1ALDH1A1HSP90AA1HSP90AB1ATR | |
| SCHEMBL4122839 | 0.83 | LMNA (0.46) | ALDH1A1RXFP1HSP90AA1HSP90AB1RBP4 | |
| SCHEMBL4112748 | 0.80 | CNR2 (0.42) | RXFP1HSP90AA1HSP90AB1LPAR1SMN1; SMN2 | |
| SCHEMBL13776193 | 0.79 | HSP90AA1 (0.41) | RXFP1HSP90AA1HSP90AB1CYP17A1S1PR3 | |
| SCHEMBL4119464 | 0.79 | LPAR1 (0.51) | ALDH1A1L3MBTL1HSP90AA1HSP90AB1LPAR1 | |
| SCHEMBL13776189 | 0.79 | HSP90AA1 (0.44) | RXFP1HSP90AA1HSP90AB1S1PR3LPAR1 | |
| SCHEMBL13775974 | 0.78 | HSP90AA1 (0.40) | ALDH1A1RXFP1HSP90AA1HSP90AB1CYP17A1 | |
| SCHEMBL19857728 | 0.78 | CYP3A4 (0.46) | ALDH1A1HSP90AA1HSP90AB1S1PR3HPGD | |
| SCHEMBL13775967 | 0.78 | CNR2 (0.41) | RXFP1HSP90AA1HSP90AB1LPAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090181942-A1 | TRICYCLIC COMPOUNDS | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2009-07-16 | — | — | US | disclosed |
| US-20090181942-A1 | TRICYCLIC COMPOUNDS | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2009-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181942-A1 | TRICYCLIC COMPOUNDS | FDFT1, COASY, HMGCR | METAP1 1240/4885ALDH1A1 1587/4885L3MBTL1 661/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.