Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | PDE5A | O76074 | 8/20 | 0.37 |
| ▸ | MERTK | Q12866 | 4/20 | 0.37 |
| ▸ | FLT3 | P36888 | 3/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 3/20 | 0.37 |
| ▸ | GAS6 | Q14393 | 3/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | GPR6 | P46095 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1377646 | 1.00 | MAPK14 (0.39) | MAPK14PDE5AMERTKFLT3TYRO3 | |
| SCHEMBL5205130 | 0.92 | PDE5A (0.42) | PDE5AMERTKFLT3TYRO3GAS6 | |
| SCHEMBL5205128 | 0.92 | PDE5A (0.42) | PDE5AMERTKFLT3TYRO3GAS6 | |
| SCHEMBL5203513 | 0.89 | MAPK14 (0.43) | MAPK14MERTKFLT3TYRO3GAS6 | |
| SCHEMBL5203505 | 0.89 | MAPK14 (0.43) | MAPK14MERTKFLT3TYRO3GAS6 | |
| SCHEMBL5203216 | 0.86 | MERTK (0.39) | MAPK14MERTKFLT3TYRO3GAS6 | |
| SCHEMBL5203220 | 0.86 | MERTK (0.39) | MAPK14MERTKFLT3TYRO3GAS6 | |
| Hydrochloric Acid SCHEMBL5206994 | 0.85 | MERTK (0.38) | MAPK14PDE5AMERTKFLT3TYRO3 | |
| Hydrochloric Acid SCHEMBL5207002 | 0.85 | MERTK (0.38) | MAPK14PDE5AMERTKFLT3TYRO3 | |
| SCHEMBL7161086 | 0.82 | MAPK14 (0.43) | MAPK14MERTKFLT3TYRO3GAS6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4743463-B2 | — | — | 2011-08-10 | — | — | JP | claimed |
| JP-2002541245-A | — | — | 2002-12-03 | — | — | JP | claimed |
| EP-1165523-A1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | Krenitsky Pharmaceuticals, Inc. (US) | 2002-01-02 | — | — | EP | claimed |
| WO-2000061562-A1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC. (US) | 2000-10-19 | — | — | WO | claimed |
| EP-1165523-A1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | Krenitsky Pharmaceuticals, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000061562-A1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC. (US) | 2000-10-19 | — | — | WO | disclosed |