Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 8/20 | 0.49 |
| ▸ | MAPKAPK2 | P49137 | 7/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | IGF1R | P08069 | 1/20 | 0.48 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.48 |
| ▸ | TSSK2 | Q96PF2 | 1/20 | 0.48 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.48 |
| ▸ | CNR1 | P21554 | 2/20 | 0.46 |
| ▸ | CNR2 | P34972 | 2/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 2/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13764318 | 0.91 | CHEK1 (0.49) | CHEK1MAPKAPK2JAK2LCKIGF1R | |
| SCHEMBL13764317 | 0.88 | CHEK1 (0.47) | CHEK1MAPKAPK2JAK2LCKIGF1R | |
| SCHEMBL13776786 | 0.85 | USP30 (0.49) | CHEK1MAPKAPK2JAK2USP30PIK3CD | |
| SCHEMBL13764319 | 0.84 | CNR1 (0.47) | CHEK1MAPKAPK2JAK2LCKIGF1R | |
| SCHEMBL13776795 | 0.83 | CHEK1 (0.57) | CHEK1MAPKAPK2JAK2LCKIGF1R | |
| SCHEMBL13259850 | 0.79 | CHEK1 (0.57) | CHEK1MAPKAPK2JAK2LCKIGF1R | |
| SCHEMBL13258871 | 0.77 | MAPKAPK2 (0.71) | CHEK1MAPKAPK2JAK2LCKIGF1R | |
| SCHEMBL13764322 | 0.75 | PIK3CD (0.42) | CNR1CNR2USP30PIK3CDALOX5 | |
| SCHEMBL13776791 | 0.75 | CHEK1 (0.49) | CHEK1MAPKAPK2JAK2LCKIGF1R | |
| SCHEMBL24096807 | 0.74 | BTK (0.40) | IGF1RCNR1CNR2USP30PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090175852-A1 | IMIDAZOPYRAZINES AS PROTEIN KINASE INHIBITORS | SCHERING CORPORATION | 2009-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090175852-A1 | IMIDAZOPYRAZINES AS PROTEIN KINASE INHIBITORS | CHEK1, CHEK2, CDKN1A | CHEK1 1/4885MAPKAPK2 43/4885JAK2 71/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.