Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 7/20 | 0.49 |
| ▸ | MAPKAPK2 | P49137 | 7/20 | 0.49 |
| ▸ | USP30 | Q70CQ3 | 6/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.45 |
| ▸ | TSSK2 | Q96PF2 | 1/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.45 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 2/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13776786 | 0.90 | USP30 (0.49) | CHEK1MAPKAPK2USP30JAK2IRAK1 | |
| SCHEMBL13776790 | 0.88 | USP30 (0.48) | USP30JAK2IRAK1PARP1PIM1 | |
| SCHEMBL13776787 | 0.85 | USP30 (0.53) | USP30JAK2IRAK1PARP1PIM1 | |
| SCHEMBL13776792 | 0.80 | CHEK1 (0.75) | CHEK1MAPKAPK2JAK2LCKIGF1R | |
| SCHEMBL13776788 | 0.75 | USP30 (0.50) | USP30JAK2IRAK1PARP1PIM1 | |
| SCHEMBL13776782 | 0.75 | CHEK1 (0.49) | CHEK1MAPKAPK2USP30JAK2LCK | |
| SCHEMBL13764318 | 0.75 | CHEK1 (0.49) | CHEK1MAPKAPK2USP30JAK2LCK | |
| SCHEMBL13258871 | 0.74 | MAPKAPK2 (0.71) | CHEK1MAPKAPK2JAK2LCKIGF1R | |
| SCHEMBL13764317 | 0.73 | CHEK1 (0.47) | CHEK1MAPKAPK2USP30JAK2LCK | |
| SCHEMBL21599063 | 0.72 | JAK3 (0.51) | USP30JAK2PIM1PIM2BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090175852-A1 | IMIDAZOPYRAZINES AS PROTEIN KINASE INHIBITORS | SCHERING CORPORATION | 2009-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090175852-A1 | IMIDAZOPYRAZINES AS PROTEIN KINASE INHIBITORS | CHEK1, CHEK2, CDKN1A | CHEK1 1/4885MAPKAPK2 43/4885USP30 1066/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.