Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 13/20 | 0.62 |
| ▸ | MAPT | P10636 | 10/20 | 0.62 |
| ▸ | HPGD | P15428 | 6/20 | 0.62 |
| ▸ | RAB9A | P51151 | 5/20 | 0.62 |
| ▸ | NPC1 | O15118 | 4/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.54 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL171847 | 0.85 | NPC1 (0.58) | L3MBTL1MAPTHPGDRAB9ANPC1 | |
| SCHEMBL22261672 | 0.84 | L3MBTL1 (0.56) | L3MBTL1MAPTHPGDRAB9ANPC1 | |
| SCHEMBL21184536 | 0.84 | L3MBTL1 (0.56) | L3MBTL1MAPTHPGDRAB9ANPC1 | |
| SCHEMBL21184526 | 0.84 | L3MBTL1 (0.56) | L3MBTL1MAPTHPGDRAB9ANPC1 | |
| SCHEMBL22261752 | 0.84 | L3MBTL1 (0.56) | L3MBTL1MAPTHPGDRAB9ANPC1 | |
| SCHEMBL22261754 | 0.84 | L3MBTL1 (0.56) | L3MBTL1MAPTHPGDRAB9ANPC1 | |
| SCHEMBL21184456 | 0.84 | L3MBTL1 (0.56) | L3MBTL1MAPTHPGDRAB9ANPC1 | |
| SCHEMBL13778593 | 0.82 | HTR1A (0.44) | L3MBTL1MAPTHPGDRAB9ANPC1 | |
| SCHEMBL13433963 | 0.81 | L3MBTL1 (0.52) | L3MBTL1MAPTHPGDRAB9ANPC1 | |
| SCHEMBL18715976 | 0.81 | L3MBTL1 (0.52) | L3MBTL1MAPTHPGDRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090170845-A1 | USE OF IMIDAZO[2,1-b]-1,3,4-THIADIAZOLE-2-SULFONAMIDE COMPOUNDS TO TREAT NEUROPATHIC PAIN | AEGERA THERAPEUTICS INC. (CA) | 2009-07-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090170845-A1 | USE OF IMIDAZO[2,1-b]-1,3,4-THIADIAZOLE-2-SULFONAMIDE COMPOUNDS TO TREAT NEUROPATHIC PAIN | SCN1B, SCN3A, SCN1A | L3MBTL1 2815/4885MAPT 2535/4885HPGD 1056/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.