Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 7/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | VNN1 | O95497 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1381950 | 0.88 | CYP1A2 (0.42) | GRM5CYP1A2VNN1 | |
| SCHEMBL3819011 | 0.84 | HSD11B1 (0.39) | GRM5CYP1A2 | |
| SCHEMBL3815565 | 0.83 | PTGER2 (0.41) | GRM5CYP1A2VNN1 | |
| SCHEMBL3810171 | 0.82 | CYP1A2 (0.41) | GRM5CYP1A2 | |
| SCHEMBL1382204 | 0.82 | SMN1; SMN2 (0.42) | GRM5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3818100 | 0.81 | CLK4 (0.36) | GRM5CYP1A2VNN1 | |
| SCHEMBL1378033 | 0.79 | KCNA5 (0.43) | — | |
| SCHEMBL1377228 | 0.79 | CYP1A2 (0.43) | GRM5CYP1A2 | |
| SCHEMBL1381975 | 0.72 | KCNA5 (0.45) | — | |
| SCHEMBL1377359 | 0.71 | NR3C2 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4719744-B2 | — | — | 2011-07-06 | — | — | JP | claimed |
| EP-1776355-A4 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO INC (US) | 2009-08-12 | — | — | EP | claimed |
| EP-1776355-A2 | POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2007-04-25 | — | — | EP | claimed |
| WO-2006014877-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2006-02-09 | — | — | WO | claimed |