Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER2 | P43116 | 8/20 | 0.41 |
| ▸ | GRM5 | P41594 | 4/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.36 |
| ▸ | VNN1 | O95497 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1378017 | 0.83 | GRM5 (0.43) | GRM5VNN1CYP1A2 | |
| SCHEMBL1381950 | 0.83 | CYP1A2 (0.42) | PTGER2GRM5VNN1ALDH1A1CYP1A2 | |
| SCHEMBL3819011 | 0.80 | HSD11B1 (0.39) | PTGER2GRM5KCNA5ALDH1A1CYP1A2 | |
| SCHEMBL3818100 | 0.80 | CLK4 (0.36) | PTGER2GRM5VNN1ALDH1A1CYP1A2 | |
| SCHEMBL1380015 | 0.75 | KCNA5 (0.45) | GRM5KCNA5VNN1ALDH1A1CYP1A2 | |
| SCHEMBL1378033 | 0.75 | KCNA5 (0.43) | PTGER2KCNA5CYP3A4 | |
| SCHEMBL1382204 | 0.73 | SMN1; SMN2 (0.42) | GRM5ALDH1A1CYP3A4MAPK1 | |
| SCHEMBL3813507 | 0.72 | NAMPT (0.42) | PTGER2GRM5CYP3A4 | |
| SCHEMBL1726534 | 0.71 | ABCB1 (0.45) | ALDH1A1CLK4CCNT1ABCB1 | |
| SCHEMBL14632483 | 0.70 | ALDH1A1 (0.51) | ALDH1A1TSHRMAPK1HSD17B10ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1776355-A4 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO INC (US) | 2009-08-12 | — | — | EP | disclosed |
| EP-1776355-A2 | POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2007-04-25 | — | — | EP | disclosed |
| WO-2006014877-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2006-02-09 | — | — | WO | disclosed |