Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 19/20 | 0.43 |
| ▸ | CTSL | P07711 | 16/20 | 0.43 |
| ▸ | CTSS | P25774 | 14/20 | 0.43 |
| ▸ | CTSB | P07858 | 4/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | CTSV | O60911 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13784263 | 0.93 | CTSK (0.46) | CTSKCTSLCTSSCTSBPSEN1 | |
| SCHEMBL13784231 | 0.77 | CTSK (0.64) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL13784220 | 0.74 | CTSK (0.49) | CTSKCTSLCTSSCTSBPSEN1 | |
| SCHEMBL4316707 | 0.71 | CTSS (0.40) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL6843731 | 0.70 | CTSK (0.64) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL13784221 | 0.70 | CTSK (0.48) | CTSKCTSLCTSSCTSBPSEN1 | |
| SCHEMBL13784222 | 0.69 | CTSK (0.47) | CTSKCTSLCTSSCTSBPSEN1 | |
| SCHEMBL5105622 | 0.69 | MC4R (0.44) | CTSKCTSLCTSSCTSB | |
| SCHEMBL4313026 | 0.68 | BCHE (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4313021 | 0.68 | BCHE (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7563784-B2 | Protease inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2009-07-21 | — | — | US | disclosed |