SCHEMBL13787017

SCHEMBL13787017

Cc1c(-c2ccccc2)n(C)c2ncccc12

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP11B2 P19099 2/20 0.51
FEN1 P39748 1/20 0.43
ALDH1A1 P00352 2/20 0.42
TSHR P16473 1/20 0.42
CYP2C19 P33261 1/20 0.42
CCNB2 O95067 1/20 0.41
CDK1 P06493 1/20 0.41
CCNB1 P14635 1/20 0.41
CDK5 Q00535 1/20 0.41
CDK5R1 Q15078 1/20 0.41
CCNB3 Q8WWL7 1/20 0.41
L3MBTL1 Q9Y468 2/20 0.41
EGFR P00533 1/20 0.40
SRC P12931 1/20 0.40
TLR7 Q9NYK1 1/20 0.40
NPC1 O15118 1/20 0.40
HSP90AA1 P07900 1/20 0.40
LRRK2 Q5S007 1/20 0.40
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2287924 0.83 FEN1 (0.43) CYP11B2FEN1ALDH1A1TSHRCYP2C19
SCHEMBL4781863 0.82 FEN1 (0.42) CYP11B2FEN1ALDH1A1TSHRCYP2C19
SCHEMBL6477966 0.78 EGFR (0.51) FEN1ALDH1A1TSHRCYP2C19L3MBTL1
SCHEMBL3223827 0.78 ALDH1A1 (0.61) FEN1ALDH1A1TSHRCYP2C19CCNB2
SCHEMBL6663570 0.77 FEN1 (0.49) CYP11B2FEN1ALDH1A1CYP2C19L3MBTL1
SCHEMBL3215841 0.76 ALDH1A1 (0.40) FEN1ALDH1A1CCNB2CDK1CCNB1
SCHEMBL8692189 0.75 FEN1 (0.49) FEN1ALDH1A1TSHRCYP2C19EGFR
SCHEMBL30373546 0.74 ALDH1A1 (0.46) FEN1ALDH1A1TSHRCYP2C19CCNB2
SCHEMBL1609990 0.73 FEN1 (0.56) FEN1ALDH1A1CYP2C19L3MBTL1EGFR
SCHEMBL6478016 0.73 ABCB1 (0.48) FEN1ALDH1A1TSHRCYP2C19L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009094287-A1 IAP INHIBITORS TETRALOGIC PHARMACEUTICAL CORPORATION (US) 2009-07-30 WO disclosed