Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 5/20 | 0.54 |
| ▸ | MERTK | Q12866 | 4/20 | 0.54 |
| ▸ | MET | P08581 | 8/20 | 0.49 |
| ▸ | KDR | P35968 | 8/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 8/20 | 0.48 |
| ▸ | FLT3 | P36888 | 2/20 | 0.47 |
| ▸ | KIT | P10721 | 3/20 | 0.46 |
| ▸ | RET | P07949 | 2/20 | 0.46 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | LYN | P07948 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL374524 | 0.90 | AXL (0.52) | AXLMERTKMETKDRPDGFRA | |
| SCHEMBL29693574 | 0.88 | AXL (0.57) | AXLMERTKMETKDRPDGFRA | |
| SCHEMBL371576 | 0.88 | AXL (0.57) | AXLMERTKMETKDRPDGFRA | |
| SCHEMBL29693565 | 0.87 | AXL (0.56) | AXLMERTKMETKDRPDGFRA | |
| SCHEMBL371852 | 0.87 | AXL (0.56) | AXLMERTKMETKDRPDGFRA | |
| SCHEMBL1788925 | 0.86 | AXL (0.57) | AXLMERTKMETKDRPDGFRA | |
| SCHEMBL371549 | 0.85 | AXL (0.67) | AXLMERTKMETKDRPDGFRA | |
| SCHEMBL20216630 | 0.83 | KDR (0.52) | AXLMERTKMETKDRPDGFRA | |
| SCHEMBL20216631 | 0.80 | MET (0.55) | AXLMERTKMETKDRPDGFRA | |
| SCHEMBL372418 | 0.80 | AXL (0.70) | AXLMERTKMETKDRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090170896-A1 | c-Met modulators and methods of use | EXELIXIS, INC. (US) | 2009-07-02 | — | — | US | disclosed |
| US-20090170896-A1 | c-Met modulators and methods of use | EXELIXIS, INC. (US) | 2009-07-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090170896-A1 | c-Met modulators and methods of use | FLT4, MET, FLT1 | AXL 239/4885MERTK 23/4885MET 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.