Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.52 |
| ▸ | MET | P08581 | 14/20 | 0.52 |
| ▸ | AXL | P30530 | 5/20 | 0.52 |
| ▸ | MERTK | Q12866 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 3/20 | 0.51 |
| ▸ | RET | P07949 | 2/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.46 |
| ▸ | KIT | P10721 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL374524 | 0.93 | AXL (0.52) | KDRPDGFRAMETAXLMERTK | |
| SCHEMBL15918385 | 0.85 | MET (0.70) | KDRPDGFRAMETAXLMERTK | |
| SCHEMBL1788925 | 0.84 | AXL (0.57) | KDRPDGFRAMETAXLMERTK | |
| SCHEMBL13787495 | 0.83 | AXL (0.54) | KDRPDGFRAMETAXLMERTK | |
| SCHEMBL371852 | 0.83 | AXL (0.56) | KDRPDGFRAMETAXLMERTK | |
| SCHEMBL29693565 | 0.83 | AXL (0.56) | KDRPDGFRAMETAXLMERTK | |
| SCHEMBL10449247 | 0.82 | MET (0.69) | KDRPDGFRAMETAXLMERTK | |
| SCHEMBL168944 | 0.81 | MET (0.60) | METAXLMERTK | |
| SCHEMBL168001 | 0.80 | AXL (0.54) | KDRMETAXLFLT3 | |
| SCHEMBL13314739 | 0.80 | MET (0.59) | KDRMETAXLFLT3KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3329918-A2 | C-MET MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2018-06-06 | — | — | EP | disclosed |