Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | GALR2 | O43603 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MPI | P34949 | 1/20 | 0.42 |
| ▸ | CCR6 | P51684 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | CTSB | P07858 | 2/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1359386 | 0.83 | ALDH1A1 (0.43) | MAPTALDH1A1NPSR1HTTSMN1; SMN2 | |
| SCHEMBL13708975 | 0.72 | ALDH1A1 (0.35) | MAPTALDH1A1NPSR1HTTSMN1; SMN2 | |
| SCHEMBL2910153 | 0.72 | MAPT (0.39) | MAPTALDH1A1NPSR1HTTSMN1; SMN2 | |
| SCHEMBL1359969 | 0.72 | ALDH1A1 (0.35) | MAPTALDH1A1NPSR1HTTSMN1; SMN2 | |
| SCHEMBL13788440 | 0.71 | TRPV1 (0.36) | MAPTALDH1A1NPSR1HTTSMN1; SMN2 | |
| SCHEMBL13468341 | 0.69 | ALDH1A1 (0.43) | MAPTALDH1A1NPSR1HTTL3MBTL1 | |
| SCHEMBL14549602 | 0.69 | MAPK1 (0.47) | MAPTALDH1A1SMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL3834788 | 0.67 | ALDH1A1 (0.57) | MAPTALDH1A1NPSR1HTTSMN1; SMN2 | |
| SCHEMBL13813006 | 0.66 | CTSB (0.47) | MAPTALDH1A1NPSR1HTTSMN1; SMN2 | |
| SCHEMBL14538405 | 0.66 | HTT (0.42) | MAPTALDH1A1NPSR1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1592686-B1 | GYRASE INHIBITORS AND USES THEREOF | VERTEX PHARMA (US) | 2009-07-08 | — | — | EP | disclosed |
| EP-1789419-B1 | GYRASE INHIBITORS AND USES THEREOF | VERTEX PHARMA (US) | 2009-06-17 | — | — | EP | disclosed |
| WO-2007056330-A1 | BENZIMIDAZOLE DERIVATIVES AS GYRASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-05-18 | — | — | WO | disclosed |