Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.35 |
| ▸ | MAT2A | P31153 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13788945 | 0.77 | ADORA2A (0.38) | ADORA2AMAT2AKDM4EALDH1A1NOTUM | |
| SCHEMBL13788908 | 0.75 | TSHR (0.36) | ADORA2AMAT2AKDM4EALDH1A1NOTUM | |
| SCHEMBL13788858 | 0.73 | CNR2 (0.40) | ADORA2AKDM4EALDH1A1 | |
| SCHEMBL4292669 | 0.68 | SMN1; SMN2 (0.33) | ADORA2AMAT2AALDH1A1ADORA3ADORA1 | |
| SCHEMBL13788904 | 0.68 | MAT2A (0.42) | MAT2AKDM4EALDH1A1NOTUMMAPT | |
| SCHEMBL13788905 | 0.64 | SMN1; SMN2 (0.38) | MAT2AALDH1A1POLBEGLN1MAPT | |
| SCHEMBL3986451 | 0.63 | JAK2 (0.36) | ADORA2AMAT2AALDH1A1POLBKDM5B | |
| SCHEMBL4745803 | 0.62 | KCNH2 (0.35) | ADORA2AMAT2AALDH1A1KDM5BADORA3 | |
| SCHEMBL11147896 | 0.61 | KDM4E (0.34) | ADORA2AKDM4EALDH1A1NOTUMPOLB | |
| SCHEMBL4487964 | 0.60 | JAK2 (0.40) | ADORA2AMAT2ANOTUMKDM5BADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090186907-A1 | Pyrazinones As Cellular Proliferation Inhibitors | E.I. DUPONT DE NEMOURS AND COMPANY (US) | 2009-07-23 | — | — | US | disclosed |
| US-20080194585-A1 | Fungicidal Pyrazine Derivatives | SHARPE PAULA LOUISE | 2008-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194585-A1 | Fungicidal Pyrazine Derivatives | CBR3, CBR1, NR0B1 | ADORA2A 2322/4885MAT2A 4013/4885KDM4E 3888/4885 |
| US-20090186907-A1 | Pyrazinones As Cellular Proliferation Inhibitors | MKI67, NR0B1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | ADORA2A 2088/4885MAT2A 4760/4885KDM4E 3719/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.