Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 3/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ALDH1A2 | O94788 | 4/20 | 0.37 |
| ▸ | ALDH1A3 | P47895 | 4/20 | 0.37 |
| ▸ | HPD | P32754 | 2/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4877684 | 0.83 | MAT2A (0.39) | MAT2AGRM5SMN1; SMN2LMNAMAPT | |
| SCHEMBL4261005 | 0.76 | HRH3 (0.35) | MAT2AALDH1A1ALDH1A2ALDH1A3HTT | |
| SCHEMBL4497287 | 0.76 | HTR2A (0.36) | MAT2AALDH1A1SMN1; SMN2ALDH1A2ALDH1A3 | |
| SCHEMBL4882519 | 0.74 | MAT2A (0.45) | MAT2ANOTUMALDH1A1LMNANPC1 | |
| SCHEMBL4882430 | 0.72 | MAT2A (0.46) | MAT2ANOTUMALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL255919 | 0.71 | KEAP1 (0.61) | NOTUMGRM5ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL13788945 | 0.70 | ADORA2A (0.38) | MAT2ANOTUMALDH1A1LMNAKDM4E | |
| SCHEMBL13788858 | 0.67 | CNR2 (0.40) | ALDH1A1SMN1; SMN2KDM4ETSHR | |
| SCHEMBL4487964 | 0.66 | JAK2 (0.40) | MAT2ANOTUMLMNANPC1MAPT | |
| SCHEMBL13788908 | 0.66 | TSHR (0.36) | MAT2ANOTUMALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090186907-A1 | Pyrazinones As Cellular Proliferation Inhibitors | E.I. DUPONT DE NEMOURS AND COMPANY (US) | 2009-07-23 | — | — | US | disclosed |
| US-20080194585-A1 | Fungicidal Pyrazine Derivatives | SHARPE PAULA LOUISE | 2008-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194585-A1 | Fungicidal Pyrazine Derivatives | CBR3, CBR1, NR0B1 | MAT2A 4013/4885NOTUM 1116/4885GRM5 93/4885 |
| US-20090186907-A1 | Pyrazinones As Cellular Proliferation Inhibitors | MKI67, NR0B1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | MAT2A 4760/4885NOTUM 3233/4885GRM5 1061/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.