Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1269423 | 0.91 | ALDH1A1 (0.39) | L3MBTL1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL1268770 | 0.90 | ALDH1A1 (0.52) | L3MBTL1ALDH1A1MAPTHTTMEN1 | |
| SCHEMBL1269882 | 0.88 | PTGDR (0.42) | L3MBTL1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL13801201 | 0.86 | ALDH1A1 (0.38) | L3MBTL1ALDH1A1MAPTHTTMEN1 | |
| SCHEMBL1269566 | 0.86 | ALDH1A1 (0.45) | L3MBTL1ALDH1A1MAPTHTTMEN1 | |
| SCHEMBL1269635 | 0.85 | ALDH1A1 (0.42) | L3MBTL1ALDH1A1MAPTHTTMEN1 | |
| SCHEMBL1268550 | 0.84 | ALDH1A1 (0.40) | L3MBTL1ALDH1A1MAPTHTTMEN1 | |
| SCHEMBL13801419 | 0.84 | MERTK (0.39) | L3MBTL1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL1268621 | 0.83 | ALDH1A1 (0.38) | L3MBTL1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL12931650 | 0.82 | ALDH1A1 (0.47) | L3MBTL1ALDH1A1MAPTHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7544702-B2 | Bisaryl-sulfonamides | AMGEN INC. (US) | 2009-06-09 | — | — | US | disclosed |
| US-7544702-B2 | Bisaryl-sulfonamides | AMGEN INC. (US) | 2009-06-09 | — | — | US | disclosed |