Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | UBE2N | P61088 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.38 |
| ▸ | LIPG | Q9Y5X9 | 3/20 | 0.37 |
| ▸ | LIPC | P11150 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | PRKACG | P22612 | 1/20 | 0.36 |
| ▸ | PRKACB | P22694 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13792793 | 0.88 | ADORA3 (0.39) | LMNATP53CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL13792168 | 0.88 | PROKR1 (0.43) | LMNASMN1; SMN2HTTUBE2NMAPT | |
| SCHEMBL13793078 | 0.88 | EGLN1 (0.41) | LMNASMN1; SMN2HTTUBE2NMAPT | |
| SCHEMBL13793151 | 0.87 | L3MBTL1 (0.41) | LMNATP53CYP3A4ESR1ADRA2A | |
| SCHEMBL13793030 | 0.87 | PPARA (0.43) | LMNAMAPTTP53CYP3A4ESR1 | |
| SCHEMBL13793100 | 0.86 | ADORA3 (0.36) | LMNAMAPTTP53CYP3A4ESR1 | |
| SCHEMBL13793029 | 0.86 | PPARG (0.38) | LMNAMAPTTP53CYP3A4CYP1A2 | |
| SCHEMBL13792786 | 0.86 | L3MBTL1 (0.42) | LMNATP53CYP3A4ESR1ADRA2A | |
| SCHEMBL13792820 | 0.85 | ADORA2A (0.40) | LMNAMAPTTP53CYP3A4ESR1 | |
| SCHEMBL13793031 | 0.84 | UTS2R (0.38) | LMNASMN1; SMN2TP53CYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7544812-B2 | For example, 2-(4-{2-[1-(4-tert-Butyl-benzyl)-3-methyl-2-oxo-imidazolidin-4-yl]-ethoxy}-2-methyl-phenoxy)-2-methyl-propionic acid, 2-(4-{3-[1-(4-tert-Butyl-benzyl)-3-methyl-2-oxo-imidazolidin-4-yl]-propyl}-2-methyl-phenoky)-2-methyl-propionic acid; for treating diabetes mellitus | ELI LILLY AND COMPANY (US) | 2009-06-09 | — | — | US | disclosed |
| US-7544812-B2 | For example, 2-(4-{2-[1-(4-tert-Butyl-benzyl)-3-methyl-2-oxo-imidazolidin-4-yl]-ethoxy}-2-methyl-phenoxy)-2-methyl-propionic acid, 2-(4-{3-[1-(4-tert-Butyl-benzyl)-3-methyl-2-oxo-imidazolidin-4-yl]-propyl}-2-methyl-phenoky)-2-methyl-propionic acid; for treating diabetes mellitus | ELI LILLY AND COMPANY (US) | 2009-06-09 | — | — | US | disclosed |