Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8327879 | 0.89 | SMN1; SMN2 (0.42) | SMN1; SMN2SRD5A1ALDH1A1GFERDDB1 | |
| SCHEMBL10726551 | 0.89 | SMN1; SMN2 (0.42) | SMN1; SMN2SRD5A1ALDH1A1GFERDDB1 | |
| SCHEMBL13476399 | 0.82 | TDP1 (0.35) | ALDH1A1DDB1CRBNMEN1KMT2A | |
| SCHEMBL11475259 | 0.78 | SLC18A3 (0.41) | SMN1; SMN2SRD5A1ALDH1A1GFERDDB1 | |
| SCHEMBL9281446 | 0.72 | ALDH1A1 (0.47) | SMN1; SMN2ALDH1A1ATMLMNAMEN1 | |
| SCHEMBL11304329 | 0.72 | MAPT (0.43) | SMN1; SMN2ALDH1A1DDB1CRBNATM | |
| SCHEMBL8390909 | 0.70 | MEN1 (0.50) | SMN1; SMN2ALDH1A1DDB1CRBNLMNA | |
| SCHEMBL7829172 | 0.70 | MEN1 (0.50) | SMN1; SMN2ALDH1A1DDB1CRBNLMNA | |
| SCHEMBL10298882 | 0.70 | SLC6A3 (0.41) | LMNAMEN1KMT2A | |
| SCHEMBL5221675 | 0.68 | SLC6A2 (0.49) | SMN1; SMN2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7544815-B2 | Process for making hydroisoindoline tachykinin receptor antagonists | MERCK & CO, INC. (US) | 2009-06-09 | — | — | US | disclosed |
| US-20070015923-A1 | Process for making hydroisoindoline tachykinin receptor antagonists | MERCK SHARP & DOHME CORP. | 2007-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070015923-A1 | Process for making hydroisoindoline tachykinin receptor antagonists | TACR1, TACR2, NPSR1 | SMN1; SMN2 2949/4885SRD5A1 1722/4885ALDH1A1 706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.