Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER2 | P43116 | 7/20 | 0.36 |
| ▸ | GRM5 | P41594 | 3/20 | 0.35 |
| ▸ | GCK | P35557 | 2/20 | 0.35 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1379181 | 0.89 | PTGER2 (0.36) | PTGER2GRM5SORT1 | |
| SCHEMBL1381518 | 0.83 | KCNA5 (0.37) | PTGER2 | |
| SCHEMBL1381052 | 0.81 | GRM5 (0.42) | GRM5 | |
| SCHEMBL1379427 | 0.81 | NPSR1 (0.47) | — | |
| SCHEMBL3812287 | 0.80 | CYP19A1 (0.33) | — | |
| SCHEMBL3814663 | 0.79 | BACE1 (0.33) | — | |
| SCHEMBL3813507 | 0.79 | NAMPT (0.42) | PTGER2GRM5 | |
| SCHEMBL1382204 | 0.78 | SMN1; SMN2 (0.42) | GRM5 | |
| SCHEMBL1382291 | 0.77 | NPC1 (0.37) | PTGER2GRM5 | |
| SCHEMBL3816707 | 0.76 | PTGS2 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4719744-B2 | — | — | 2011-07-06 | — | — | JP | claimed |
| EP-1776355-A4 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO INC (US) | 2009-08-12 | — | — | EP | claimed |
| EP-1776355-A2 | POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2007-04-25 | — | — | EP | claimed |
| WO-2006014877-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2006-02-09 | — | — | WO | claimed |