Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.56 |
| ▸ | LYN | P07948 | 1/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | USP7 | Q93009 | 2/20 | 0.39 |
| ▸ | USP47 | Q96K76 | 2/20 | 0.39 |
| ▸ | SCARB1 | Q8WTV0 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13797998 | 0.87 | MAPK14 (0.61) | MAPK14LYNMAPK9BRAFSCARB1 | |
| SCHEMBL13359211 | 0.86 | MAPK14 (0.40) | MAPK14LYNMAPK9USP7USP47 | |
| SCHEMBL13359224 | 0.86 | MAPK14 (0.62) | MAPK14LYNMAPK9BRAFSCARB1 | |
| SCHEMBL13798001 | 0.86 | MAPK14 (0.60) | MAPK14LYNMAPK9BRAFSCARB1 | |
| SCHEMBL13797936 | 0.84 | MAPK14 (0.68) | MAPK14LYNMAPK9BRAFSCARB1 | |
| SCHEMBL13811033 | 0.84 | MAPK14 (0.58) | MAPK14LYNMAPK9BRAFSCARB1 | |
| SCHEMBL13359213 | 0.84 | MAPK14 (0.60) | MAPK14LYNMAPK9BRAFUSP7 | |
| SCHEMBL13797941 | 0.83 | MAPK14 (0.68) | MAPK14LYNMAPK9BRAFSCARB1 | |
| SCHEMBL13797930 | 0.81 | MAPK14 (0.73) | MAPK14LYNMAPK9BRAFSCARB1 | |
| SCHEMBL3257780 | 0.79 | LYN (0.56) | MAPK14LYNMAPK9BRAFMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7550461-B2 | Benzofuran and benzothiophene compounds useful in treating cytokine mediated diseases | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-06-23 | — | — | US | disclosed |
| US-7550461-B2 | Benzofuran and benzothiophene compounds useful in treating cytokine mediated diseases | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-06-23 | — | — | US | disclosed |