Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | USP7 | Q93009 | 2/20 | 0.35 |
| ▸ | USP47 | Q96K76 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13359156 | 0.87 | MAPK14 (0.44) | MAPK14MEN1KMT2ALMNARAB9A | |
| SCHEMBL13797948 | 0.86 | MAPK14 (0.56) | MAPK14MEN1KMT2ALMNANPC1 | |
| SCHEMBL13359286 | 0.84 | MAPK14 (0.49) | MAPK14MEN1KMT2ALMNANPC1 | |
| SCHEMBL13359163 | 0.80 | ALDH1A1 (0.42) | MAPK14MEN1KMT2ALMNANPC1 | |
| SCHEMBL3252599 | 0.74 | TDP1 (0.43) | MEN1KMT2ALMNAALDH1A1MAPK1 | |
| SCHEMBL13359141 | 0.74 | LYN (0.45) | MAPK14MEN1KMT2ALMNANPC1 | |
| SCHEMBL13797998 | 0.73 | MAPK14 (0.61) | MAPK14LYNMAPK9 | |
| SCHEMBL13359224 | 0.72 | MAPK14 (0.62) | MAPK14LYNMAPK9 | |
| SCHEMBL13798001 | 0.72 | MAPK14 (0.60) | MAPK14LYNMAPK9 | |
| SCHEMBL13359264 | 0.71 | LYN (0.59) | MAPK14MEN1KMT2ALMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1497278-B1 | HETEROCYCLIC AMIDE DERIVATIVES AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMA (US) | 2010-05-26 | — | — | EP | disclosed |